Significant Disease Burden | Sjögren's Disease

Sjögren’s disease is a constant presence causing daily challenges that impact quality of life.

Sjögren's disease can affect physical, emotional, and social well-being²

The most common symptoms in Sjögren's disease (SjD), including excessive dryness, severe fatigue, and chronic pain, can be debilitating for patients.⁴

Dryness symptoms are one of the top reasons patients seek care¹

Up to 96% of patients report joint pain, which can be debilitating⁵

Patients who have dental decay report lower quality of life than other patients with SjD³

Fatigue in SjD can be profound and make it difficult to concentrate, and is associated with depression and anxiety⁶

Understanding the burden of Sjögren’s disease

Dr Brian Porter speaks with Paula, a patient with Sjögren's disease, about the burden caused by her disease.

High systemic disease activity has been associated with reduced quality of life.⁷

What could be the indicators of underlying disease activity?

Why symptomatic treatment may not be enough

*Based on the "Living with SjD" survey assessing demographics, symptoms, QOL, cost, and treatment in adult patients with SjD (N=2961).¹

QOL, quality of life.

References: 1. McCoy SS, Woodham M, Bunya VY, et al. A comprehensive overview of living with Sjögren's: results of a National Sjögren’s Foundation survey. Clin Rheumatol. 2022;41(7):2071-2078. 2. Perella C, Steenackers M, Robbins B, et al. Patient experience of Sjögren's disease and its multifaceted impact on patients' lives. Rheumatol Ther. 2023;10:601-614. 3. McCoy SS, Bartels CM, Saldanha IJ, et al. National Sjögren's Foundation survey: burden of oral and systemic involvement on quality of life. J Rheumatol. 2021;48(7):1029-1036. 4. Mariette X, Criswell LA. Primary Sjögren's syndrome. N Engl J Med. 2018;378(10):931-939. 5. Rozis M, Vlamis J, Vasiliadis E, Mavragani C, Pneumaticos S, Evangelopoulos DS. Musculoskeletal manifestations in Sjogren's syndrome: an orthopedic point of view. J Clin Med. 2021;10(8):1574. doi:10:3390/jcm10081574 6. Cui Y, Xia L, Li L, Zhao Q, Chen S, Gu Z. Anxiety and depression in primary Sjögren's syndrome: a cross-sectional study. BMC Psychiatry. 2018;18(1):131. doi:10.1186/s12888-018-1715-x 7. Lendrem D, Mitchell S, McMeekin P, et al. Do the EULAR Sjögren's syndrome outcome measures correlate with health status in primary Sjögren's syndrome? Rheumatology (Oxford). 2015;54(4):655-659.